Ontology highlight
ABSTRACT:
SUBMITTER: Lu F
PROVIDER: S-EPMC2929037 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Lu Feng F Lim Chae Seung CS Nam Deok Hwa DH Kim Kwonkee K Lin Khin K Kim Tong-Soo TS Lee Hyeong-Woo HW Chen Jun-Hu JH Wang Yue Y Sattabongkot Jetsumon J Han Eun-Taek ET
The American journal of tropical medicine and hygiene 20100901 3
Parasite dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) are known target enzymes of antifolate drugs used for the treatment and prophylaxis of persons with malaria. We sequenced the Plasmodium vivax dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes to examine the prevalence and extent of point mutations in isolates from malaria-endemic countries. Double mutations (S58R and S117N) or quadruple mutations (F57L/I, S58R, T61M, and S117T) in the pvdhfr g ...[more]