Ontology highlight
ABSTRACT:
SUBMITTER: Huang D
PROVIDER: S-EPMC10819570 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Huang Daowei D Chen Ying Y Yang Jixia J Zhao Bingyang B Wang Shouying S Chai Tingting T Cui Jie J Zhou Xiaolei X Shang Zhenhua Z
Molecules (Basel, Switzerland) 20240118 2
Mer and c-Met kinases, which are commonly overexpressed in various tumors, are ideal targets for the development of antitumor drugs. This study focuses on the design, synthesis, and evaluation of several 2-substituted aniline pyrimidine derivatives as highly potent dual inhibitors of Mer and c-Met kinases for effective tumor treatment. Compound <b>18c</b> emerged as a standout candidate, demonstrating robust inhibitory activity against Mer and c-Met kinases, with IC<sub>50</sub> values of 18.5 ± ...[more]