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On Water Arrangements in Right- and Left-Handed DNA Structures.

ABSTRACT: DNA requires hydration to maintain its structural integrity. Crystallographic analyses have enabled patterns of water arrangements to be visualized. We survey these water motifs in this review, focusing on left- and right-handed duplex and quadruplex DNAs, together with the i-motif. Common patterns of linear spines of water organization in grooves have been identified and are widely prevalent in right-handed duplexes and quadruplexes. By contrast, a left-handed quadruplex has a distinctive wheel of hydration populating the almost completely circular single groove in this structure.

SUBMITTER: Yatsunyk LA

PROVIDER: S-EPMC10820154 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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On Water Arrangements in Right- and Left-Handed DNA Structures.

Yatsunyk Liliya A LA Neidle Stephen S

Molecules (Basel, Switzerland) 20240119 2

DNA requires hydration to maintain its structural integrity. Crystallographic analyses have enabled patterns of water arrangements to be visualized. We survey these water motifs in this review, focusing on left- and right-handed duplex and quadruplex DNAs, together with the i-motif. Common patterns of linear spines of water organization in grooves have been identified and are widely prevalent in right-handed duplexes and quadruplexes. By contrast, a left-handed quadruplex has a distinctive wheel ...[more]

PMID: 38276583

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