Ontology highlight
ABSTRACT:
SUBMITTER: Koosha E
PROVIDER: S-EPMC10820745 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Koosha Elham E Brenna Connor T A CTA Ashique Amir M AM Jain Niteesh N Ovens Katie K Koike Toshiyasu T Kitagawa Hiroshi H Eames B Frank BF
Development (Cambridge, England) 20240112 2
During endochondral ossification, chondrocytes secrete a proteoglycan (PG)-rich extracellular matrix that can inhibit the process of cartilage maturation, including expression of Ihh and Col10a1. Because bone morphogenetic proteins (BMPs) can promote cartilage maturation, we hypothesized that cartilage PGs normally inhibit BMP signalling. Accordingly, BMP signalling was evaluated in chondrocytes of wild-type and PG mutant (fam20b-/-) zebrafish and inhibited with temporal control using the drug D ...[more]