Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC2924163 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Zhou Zheng Z Xie Jianxin J Lee Daehoon D Liu Yu Y Jung Jiung J Zhou Lijuan L Xiong Shan S Mei Lin L Xiong Wen-Cheng WC
Developmental cell 20100701 1
Neogenin has been identified as a receptor for the neuronal axon guidance cues netrins and RGMs (repulsive guidance molecules). Here we provide evidence for neogenin in regulating endochondral bone development and BMP (bone morphogenetic protein) signaling. Neogenin-deficient mice were impaired in digit/limb development and endochondral ossification. BMP2 induction of Smad1/5/8 phosphorylation and Runx2 expression, but not noncanonical p38 MAPK activation, was reduced in chondrocytes from neogen ...[more]