Dataset Information

Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography.

ABSTRACT:

Introduction

Lung transplantation (LT) recipients are at risk of bone mineral density (BMD) loss. Pre- and post-LT BMD loss has been reported in some cross-sectional studies; however, there are limited studies regarding the serial BMD change in LT recipients. The aim of this study was to investigate the serial BMD changes and the clinical characteristics associated with BMD decline.

Methods

This was a single-center, retrospective observational study. BMD was serially measured in thoracic vertebral bodies (Th4, 7, 10) using computed tomography (CT) before and 3 and 12 months after LT. The frequency of osteoporosis and factors associated with pre-LT osteoporosis and post-LT BMD loss were evaluated. The frequency of post-LT compression fracture and its associated factors were also analyzed.

Results

This study included 128 adult LT recipients. LT recipients had decreased BMD (151.8 ± 42.2 mg/mL) before LT compared with age-, sex-, and smoking index-matched controls (176.2 ± 35.7 mg/mL). The diagnosis of COPD was associated with pre-LT osteoporosis. LT recipients experience further BMD decline after transplantation, and the percentage of recipients classified as exhibiting osteoporosis increased from 20% at baseline to 43% at 12 months. Recipients who had been taking no or small doses of glucocorticoids before LT had rapid BMD loss after LT. Early bisphosphonate use (within 3 months) after LT attenuated BMD loss and decreased new-onset compression fracture.

Conclusion

LT recipients are at high risk for BMD loss and compression fracture after LT. Early bisphosphonate use may decrease BMD loss and compression fracture.

SUBMITTER: Mori R

PROVIDER: S-EPMC10823555 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography.

Mori Ryobu R Handa Tomohiro T Ohsumi Akihiro A Ikezoe Kohei K Tanizawa Kiminobu K Uozumi Ryuji R Tanabe Naoya N Oguma Tsuyoshi T Sakamoto Ryo R Hamaji Masatsugu M Nakajima Daisuke D Yutaka Yojiro Y Tanaka Satona S Yamada Yoshito Y Oshima Yohei Y Sato Susumu S Fukui Motonari M Date Hiroshi H Hirai Toyohiro T

Respiration; international review of thoracic diseases 20231205 1

<h4>Introduction</h4>Lung transplantation (LT) recipients are at risk of bone mineral density (BMD) loss. Pre- and post-LT BMD loss has been reported in some cross-sectional studies; however, there are limited studies regarding the serial BMD change in LT recipients. The aim of this study was to investigate the serial BMD changes and the clinical characteristics associated with BMD decline.<h4>Methods</h4>This was a single-center, retrospective observational study. BMD was serially measured in t ...[more]

PMID: 38052185

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Dataset Information

Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography.

Introduction

Methods

Results

Conclusion

Publications

Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography.

Similar Datasets

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