Dataset Information

Efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke: a meta-analysis.

ABSTRACT:

Objective

This meta-analysis and systematic review were conducted to comprehensively evaluate the efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke.

Method

We conducted a manual search of electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, with a search deadline set for February 1, 2023. Data analysis was performed using Stata version 15.0.

Result

A total of 9 randomized controlled studies were included, involving a total of 316 people, including 159 mesenchymal stem cells and 147 control groups. Results of meta-analysis: Compared to a placebo group, the administration of mesenchymal stem cells resulted in a significant reduction in the National Institutes of Health Stroke Scale (NIHSS) scores among patients diagnosed with acute ischemic stroke [SMD=-0.99,95% CI (-1.93, -0.05)]. Compared to placebo, barthel index [SMD = 0.48,95% CI (-0.55,1.51)], modified rankin score [SMD = 0.45, 95% CI (1.11, 0.21)], adverse events (RR = 0.68, 95% CI (0.40, 1.17)] the difference was not statistically significant.

Conclusion

Based on current studies, mesenchymal stem cell transplantation can ameliorate neurological deficits in patients with ischemic stroke to a certain extent without increasing adverse reactions. However, there was no significant effect on Barthel index and Modified Rankin score.

SUBMITTER: Huang H

PROVIDER: S-EPMC10823675 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke: a meta-analysis.

Huang Huanjia H Zhang Jian J Lin Jinmei J Shi Shengliang S

BMC neurology 20240129 1

<h4>Objective</h4>This meta-analysis and systematic review were conducted to comprehensively evaluate the efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke.<h4>Method</h4>We conducted a manual search of electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, with a search deadline set for February 1, 2023. Data analysis was performed using Stata version 15.0.<h4>Result</h4>A total of 9 randomized controlled studies were include ...[more]

PMID: 38287288

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Dataset Information

Efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke: a meta-analysis.

Objective

Method

Result

Conclusion

Publications

Efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke: a meta-analysis.

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