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Mn(iii), Fe(iii) and Zn(ii)-serum albumin as innovative multicolour contrast agents for photoacoustic imaging.

ABSTRACT: Here we propose innovative photoacoustic imaging (PAI) contrast agents, based on the loading of Mn(iii)-, Fe(iii)- or Zn(ii)-protoporphyrin IX in serum albumin. These systems show different absorption wavelengths, opening the way to multicolor PA imaging. They were characterized in vitro for assessing stability, biocompatibility, and their optical and contrastographic properties. Finally, a proof of concept in vivo study was carried out in breast cancer bearing mice, to evaluate its effectiveness for cancer imaging.

SUBMITTER: Di Gregorio E

PROVIDER: S-EPMC10825928 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Mn(iii), Fe(iii) and Zn(ii)-serum albumin as innovative multicolour contrast agents for photoacoustic imaging.

Di Gregorio Enza E Scarciglia Angelo A Amaolo Alessandro A Ferrauto Giuseppe G

Nanoscale advances 20231224 3

Here we propose innovative photoacoustic imaging (PAI) contrast agents, based on the loading of Mn(iii)-, Fe(iii)- or Zn(ii)-protoporphyrin IX in serum albumin. These systems show different absorption wavelengths, opening the way to multicolor PA imaging. They were characterized <i>in vitro</i> for assessing stability, biocompatibility, and their optical and contrastographic properties. Finally, a proof of concept <i>in vivo</i> study was carried out in breast cancer bearing mice, to evaluate it ...[more]

PMID: 38298593

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