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Fe(III)-templated Gd(III) self-assemblies-a new route toward macromolecular MRI contrast agents.

ABSTRACT: The self-assembly of supramolcular clusters of Gd(III) hydroxypyridinone complexes, templated by an Fe(III) terephthalamide center, is presented. The peripheral Gd(III) ions are each coordinated by two water molecules which exchange rapidly with the bulk solvent. These properties, along with the high rigidity of the supramolecules, efficiently increase the rotational correlation times of the cluster, resulting in high relaxivities at high magnetic fields and hence making these complexes good candidates for MRI contrast agents.

SUBMITTER: Pierre VC

PROVIDER: S-EPMC3190973 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

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Fe(III)-templated Gd(III) self-assemblies-a new route toward macromolecular MRI contrast agents.

Pierre Valérie C VC Botta Mauro M Aime Silvio S Raymond Kenneth N KN

Journal of the American Chemical Society 20060701 29

The self-assembly of supramolcular clusters of Gd(III) hydroxypyridinone complexes, templated by an Fe(III) terephthalamide center, is presented. The peripheral Gd(III) ions are each coordinated by two water molecules which exchange rapidly with the bulk solvent. These properties, along with the high rigidity of the supramolecules, efficiently increase the rotational correlation times of the cluster, resulting in high relaxivities at high magnetic fields and hence making these complexes good can ...[more]

PMID: 16848429

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