Ontology highlight
ABSTRACT:
SUBMITTER: Shin GC
PROVIDER: S-EPMC10834952 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Shin Gu-Choul GC Lee Hyeong Min HM Kim Nayeon N Seo Sang-Uk SU Kim Kwang Pyo KP Kim Kyun-Hwan KH
Experimental & molecular medicine 20240110 1
Tumor necrosis factor superfamily (TNFSF) resistance contributes to the development and progression of tumors and resistance to various cancer therapies. Tumor-intrinsic alterations involved in the adaptation to the TNFSF response remain largely unknown. Here, we demonstrate that protein kinase C substrate 80K-H (PRKCSH) abundance in lung cancers boosts oncogenic IGF1R activation, leading to TNFSF resistance. PRKCSH abundance is correlated with IGF1R upregulation in lung cancer tissues. Specific ...[more]