Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
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ABSTRACT:
SUBMITTER: Wang A
PROVIDER: S-EPMC10841479 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Wang Anqi A Shen Jiayi J Rodriguez Alex A AA Saunders Edward J EJ Chen Fei F Janivara Rohini R Darst Burcu F BF Sheng Xin X Xu Yili Y Chou Alisha J AJ Benlloch Sara S Dadaev Tokhir T Brook Mark N MN Plym Anna A Sahimi Ali A Hoffman Thomas J TJ Takahashi Atushi A Matsuda Koichi K Momozawa Yukihide Y Fujita Masashi M Laisk Triin T Figuerêdo Jéssica J Muir Kenneth K Ito Shuji S Liu Xiaoxi X Uchio Yuji Y Kubo Michiaki M Kamatani Yoichiro Y Lophatananon Artitaya A Wan Peggy P Andrews Caroline C Lori Adriana A Choudhury Parichoy P PP Schleutker Johanna J Tammela Teuvo L J TLJ Sipeky Csilla C Auvinen Anssi A Giles Graham G GG Southey Melissa C MC MacInnis Robert J RJ Cybulski Cezary C Wokolorczyk Dominika D Lubinski Jan J Rentsch Christopher T CT Cho Kelly K Mcmahon Benjamin H BH Neal David E DE Donovan Jenny L JL Hamdy Freddie C FC Martin Richard M RM Nordestgaard Borge G BG Nielsen Sune F SF Weischer Maren M Bojesen Stig E SE Røder Andreas A Stroomberg Hein V HV Batra Jyotsna J Chambers Suzanne S Horvath Lisa L Clements Judith A JA Tilly Wayne W Risbridger Gail P GP Gronberg Henrik H Aly Markus M Szulkin Robert R Eklund Martin M Nordstrom Tobias T Pashayan Nora N Dunning Alison M AM Ghoussaini Maya M Travis Ruth C RC Key Tim J TJ Riboli Elio E Park Jong Y JY Sellers Thomas A TA Lin Hui-Yi HY Albanes Demetrius D Weinstein Stephanie S Cook Michael B MB Mucci Lorelei A LA Giovannucci Edward E Lindstrom Sara S Kraft Peter P Hunter David J DJ Penney Kathryn L KL Turman Constance C Tangen Catherine M CM Goodman Phyllis J PJ Thompson Ian M IM Hamilton Robert J RJ Fleshner Neil E NE Finelli Antonio A Parent Marie-Élise MÉ Stanford Janet L JL Ostrander Elaine A EA Koutros Stella S Beane Freeman Laura E LE Stampfer Meir M Wolk Alicja A Håkansson Niclas N Andriole Gerald L GL Hoover Robert N RN Machiela Mitchell J MJ Sørensen Karina Dalsgaard KD Borre Michael M Blot William J WJ Zheng Wei W Yeboah Edward D ED Mensah James E JE Lu Yong-Jie YJ Zhang Hong-Wei HW Feng Ninghan N Mao Xueying X Wu Yudong Y Zhao Shan-Chao SC Sun Zan Z Thibodeau Stephen N SN McDonnell Shannon K SK Schaid Daniel J DJ West Catharine M L CML Barnett Gill G Maier Christiane C Schnoeller Thomas T Luedeke Manuel M Kibel Adam S AS Drake Bettina F BF Cussenot Olivier O Cancel-Tassin Geraldine G Menegaux Florence F Truong Thérèse T Koudou Yves Akoli YA John Esther M EM Grindedal Eli Marie EM Maehle Lovise L Khaw Kay-Tee KT Ingles Sue A SA Stern Mariana C MC Vega Ana A Gómez-Caamaño Antonio A Fachal Laura L Rosenstein Barry S BS Kerns Sarah L SL Ostrer Harry H Teixeira Manuel R MR Paulo Paula P Brandão Andreia A Watya Stephen S Lubwama Alexander A Bensen Jeannette T JT Butler Ebonee N EN Mohler James L JL Taylor Jack A JA Kogevinas Manolis M Dierssen-Sotos Trinidad T Castaño-Vinyals Gemma G Cannon-Albright Lisa L Teerlink Craig C CC Huff Chad D CD Pilie Patrick P Yu Yao Y Bohlender Ryan J RJ Gu Jian J Strom Sara S SS Multigner Luc L Blanchet Pascal P Brureau Laurent L Kaneva Radka R Slavov Chavdar C Mitev Vanio V Leach Robin J RJ Brenner Hermann H Chen Xuechen X Holleczek Bernd B Schöttker Ben B Klein Eric A EA Hsing Ann W AW Kittles Rick A RA Murphy Adam B AB Logothetis Christopher J CJ Kim Jeri J Neuhausen Susan L SL Steele Linda L Ding Yuan Chun YC Isaacs William B WB Nemesure Barbara B Hennis Anselm J M AJM Carpten John J Pandha Hardev H Michael Agnieszka A De Ruyck Kim K De Meerleer Gert G Ost Piet P Xu Jianfeng J Razack Azad A Lim Jasmine J Teo Soo-Hwang SH Newcomb Lisa F LF Lin Daniel W DW Fowke Jay H JH Neslund-Dudas Christine M CM Rybicki Benjamin A BA Gamulin Marija M Lessel Davor D Kulis Tomislav T Usmani Nawaid N Abraham Aswin A Singhal Sandeep S Parliament Matthew M Claessens Frank F Joniau Steven S Van den Broeck Thomas T Gago-Dominguez Manuela M Castelao Jose Esteban JE Martinez Maria Elena ME Larkin Samantha S Townsend Paul A PA Aukim-Hastie Claire C Bush William S WS Aldrich Melinda C MC Crawford Dana C DC Srivastava Shiv S Cullen Jennifer J Petrovics Gyorgy G Casey Graham G Wang Ying Y Tettey Yao Y Lachance Joseph J Tang Wei W Biritwum Richard B RB Adjei Andrew A AA Tay Evelyn E Truelove Ann A Niwa Shelley S Yamoah Kosj K Govindasami Koveela K Chokkalingam Anand P AP Keaton Jacob M JM Hellwege Jacklyn N JN Clark Peter E PE Jalloh Mohamed M Gueye Serigne M SM Niang Lamine L Ogunbiyi Olufemi O Shittu Olayiwola O Amodu Olukemi O Adebiyi Akindele O AO Aisuodionoe-Shadrach Oseremen I OI Ajibola Hafees O HO Jamda Mustapha A MA Oluwole Olabode P OP Nwegbu Maxwell M Adusei Ben B Mante Sunny S Darkwa-Abrahams Afua A Diop Halimatou H Gundell Susan M SM Roobol Monique J MJ Jenster Guido G van Schaik Ron H N RHN Hu Jennifer J JJ Sanderson Maureen M Kachuri Linda L Varma Rohit R McKean-Cowdin Roberta R Torres Mina M Preuss Michael H MH Loos Ruth J F RJF Zawistowski Matthew M Zöllner Sebastian S Lu Zeyun Z Van Den Eeden Stephen K SK Easton Douglas F DF Ambs Stefan S Edwards Todd L TL Mägi Reedik R Rebbeck Timothy R TR Fritsche Lars L Chanock Stephen J SJ Berndt Sonja I SI Wiklund Fredrik F Nakagawa Hidewaki H Witte John S JS Gaziano J Michael JM Justice Amy C AC Mancuso Nick N Terao Chikashi C Eeles Rosalind A RA Kote-Jarai Zsofia Z Madduri Ravi K RK Conti David V DV Haiman Christopher A CA
Nature genetics 20231109 12
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk ...[more]