A complex prediction: three-dimensional model of the yeast exosome.
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ABSTRACT:
SUBMITTER: Aloy P
PROVIDER: S-EPMC1084189 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Publications
A complex prediction: three-dimensional model of the yeast exosome.
Aloy Patrick P Ciccarelli Francesca D FD Leutwein Christina C Gavin Anne-Claude AC Superti-Furga Giulio G Bork Peer P Bottcher Bettina B Russell Robert B RB Russell Robert B RB
EMBO reports 20020701 7
We present a model of the yeast exosome based on the bacterial degradosome component polynucleotide phosphorylase (PNPase). Electron microscopy shows the exosome to resemble PNPase but with key differences likely related to the position of RNA binding domains, and to the location of domains unique to the exosome. We use various techniques to reduce the many possible models of exosome subunits based on PNPase to just one. The model suggests numerous experiments to probe exosome function, particul ...[more]
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