Ontology highlight
ABSTRACT:
SUBMITTER: Liu JJ
PROVIDER: S-EPMC5129878 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Cell research 20160513 7
The eukaryotic multi-subunit RNA exosome complex plays crucial roles in 3'-to-5' RNA processing and decay. Rrp6 and Ski7 are the major cofactors for the nuclear and cytoplasmic exosomes, respectively. In the cytoplasm, Ski7 helps the exosome to target mRNAs for degradation and turnover via a through-core pathway. However, the interaction between Ski7 and the exosome complex has remained unclear. The transaction of RNA substrates within the exosome is also elusive. In this work, we used single-pa ...[more]