Ontology highlight
ABSTRACT:
SUBMITTER: Tujebajeva RM
PROVIDER: S-EPMC1084265 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Tujebajeva R M RM Copeland P R PR Xu X M XM Carlson B A BA Harney J W JW Driscoll D M DM Hatfield D L DL Berry M J MJ
EMBO reports 20000801 2
Decoding UGA as selenocysteine requires a unique tRNA, a specialized elongation factor, and specific secondary structures in the mRNA, termed SECIS elements. Eukaryotic SECIS elements are found in the 3' untranslated region of selenoprotein mRNAs while those in prokaryotes occur immediately downstream of UGA. Consequently, a single eukaryotic SECIS element can serve multiple UGA codons, whereas prokaryotic SECIS elements only function for the adjacent UGA, suggesting distinct mechanisms for reco ...[more]