Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.
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ABSTRACT:
SUBMITTER: Xie Y
PROVIDER: S-EPMC3035430 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.
Xie Yun Y Dix Andrew V AV Tor Yitzhak Y
Chemical communications (Cambridge, England) 20100513 30
A FRET assembly reports antibiotic affinities to two different RNA targets. A binder was labeled with a fluorophore that acts both as an acceptor for the emissive nucleoside on the bacterial A-site and a donor fluorophore for the terminally-labeled human A-site. Unlabeled drugs were used to dissociate the labeled antibiotic. ...[more]
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