Ontology highlight
ABSTRACT:
SUBMITTER: Klein Geltink RI
PROVIDER: S-EPMC10863625 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Klein Geltink Ramon I RI Edwards-Hicks Joy J Apostolova Petya P O'Sullivan David D Sanin David E DE Patterson Annette E AE Puleston Daniel J DJ Ligthart Nina A M NAM Buescher Joerg M JM Grzes Katarzyna M KM Kabat Agnieszka M AM Stanczak Michal M Curtis Jonathan D JD Hässler Fabian F Uhl Franziska M FM Fabri Mario M Zeiser Robert R Pearce Edward J EJ Pearce Erika L EL
Nature metabolism 20200803 8
CD8<sup>+</sup> effector T (T<sub>E</sub>) cell proliferation and cytokine production depends on enhanced glucose metabolism. However, circulating T cells continuously adapt to glucose fluctuations caused by diet and inter-organ metabolite exchange. Here we show that transient glucose restriction (TGR) in activated CD8<sup>+</sup> T<sub>E</sub> cells metabolically primes effector functions and enhances tumour clearance in mice. Tumour-specific TGR CD8<sup>+</sup> T<sub>E</sub> cells co-cultured ...[more]