Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming.
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ABSTRACT:
SUBMITTER: Zhai X
PROVIDER: S-EPMC8641941 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Mitochondrial C1qbp promotes differentiation of effector CD8<sup>+</sup> T cells via metabolic-epigenetic reprogramming.
Zhai Xingyuan X Liu Kai K Fang Hongkun H Zhang Quan Q Gao Xianjun X Liu Fang F Zhou Shangshang S Wang Xinming X Niu Yujia Y Hong Yazhen Y Lin Shu-Hai SH Liu Wen-Hsien WH Xiao Changchun C Li Qiyuan Q Xiao Nengming N
Science advances 20211203 49
Early-activated CD8<sup>+</sup> T cells increase both aerobic glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). However, whether and how the augmentation of OXPHOS regulates differentiation of effector CD8<sup>+</sup> T cell remains unclear. Here, we found that C1qbp was intrinsically required for such differentiation in antiviral and antitumor immune responses. Activated <i>C1qbp</i>-deficient CD8<sup>+</sup> T cells failed to increase mitochondrial respiratory capacities, result ...[more]
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