Ontology highlight
ABSTRACT:
SUBMITTER: Palmer D
PROVIDER: S-EPMC10865898 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Palmer Dakota D Cayton Christelle A CA Scott Alexandra A Lin Iris I Newell Bailey B Paulson Anika A Weberg Morgan M Richard Jocelyn M JM
Cell reports 20240108 1
Reward-predictive cues acquire motivating and reinforcing properties that contribute to the escalation and relapse of drug use in addiction. The ventral pallidum (VP) and ventral tegmental area (VTA) are two key nodes in brain reward circuitry implicated in addiction and cue-driven behavior. In the current study, we use in vivo fiber photometry and optogenetics to record from and manipulate VP→VTA in rats performing a discriminative stimulus task to determine the role these neurons play in invig ...[more]