Chronic exercise improves hepatic acylcarnitine handling.
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ABSTRACT:
SUBMITTER: Hernandez-Saavedra D
PROVIDER: S-EPMC10867450 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
Chronic exercise improves hepatic acylcarnitine handling.
Hernández-Saavedra Diego D Hinkley J Matthew JM Baer Lisa A LA Pinckard Kelsey M KM Vidal Pablo P Nirengi Shinsuke S Brennan Andrea M AM Chen Emily Y EY Narain Niven R NR Bussberg Valerie V Tolstikov Vladimir V VV Kiebish Michael A MA Markunas Christina C Ilkayeva Olga O Goodpaster Bret H BH Newgard Christopher B CB Goodyear Laurie J LJ Coen Paul M PM Stanford Kristin I KI
iScience 20240201 3
Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (AC) (C12-C16) are lower in active/endurance trained human subjects compared to sedentary controls, and this is correlated with elevated cardiorespiratory fitness and reduced adiposity. In mice, exercise reduced serum AC and increased liver AC, and this was accompanied by a marked increase ...[more]
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