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Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis.

ABSTRACT: During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.

SUBMITTER: Silbaq FS

PROVIDER: S-EPMC108703 | biostudies-literature | 1998 Nov

REPOSITORIES: biostudies-literature

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Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis.

Silbaq F S FS Cho S N SN Cole S T ST Brennan P J PJ

Infection and immunity 19981101 11

During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment. ...[more]

PMID: 9784577

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Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein.

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| S-EPMC108256 | biostudies-literature

Isolation and sequencing of the gene coding for an antigenic 34-kilodalton protein of Mycobacterium paratuberculosis.

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Novel 33-kilodalton lipoprotein from Mycobacterium leprae.

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Sequence and immunological characterization of a serine-rich antigen from Mycobacterium leprae.

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Functional characterization of a small heat shock protein from Mycobacterium leprae.

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Use of the immunodominant 18-kiloDalton small heat shock protein as a serological marker for exposure to Mycobacterium ulcerans.

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A 55-kilodalton immunodominant antigen of Porphyromonas gingivalis W50 has arisen via horizontal gene transfer.

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| S-EPMC96442 | biostudies-literature

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