Ontology highlight
ABSTRACT:
SUBMITTER: Maeda Y
PROVIDER: S-EPMC128180 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Maeda Yumi Y Makino Masahiko M Crick Dean C DC Mahapatra Sebabrata S Srisungnam Sopa S Takii Takemasa T Kashiwabara Yoshiko Y Brennan Patrick J PJ
Infection and immunity 20020801 8
A novel Mycobacterium leprae lipoprotein LpK (accession no. ML0603) was identified from the genomic database. The 1,116-bp open reading frame encodes a 371-amino-acid precursor protein with an N-terminal signal sequence and a consensus motif for lipid conjugation. Expression of the protein, LpK, in Escherichia coli revealed a 33-kDa protein, and metabolic labeling experiments and globomycin treatment proved that the protein was lipidated. Fractionation of M. leprae demonstrated that this lipopro ...[more]