Conversion of Staphylococcus epidermidis strains from commensal to invasive by expression of the ica locus encoding production of biofilm exopolysaccharide.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC1087319 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
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Conversion of Staphylococcus epidermidis strains from commensal to invasive by expression of the ica locus encoding production of biofilm exopolysaccharide.
Li Hualin H Xu Lin L Wang Jianping J Wen Yumei Y Vuong Cuong C Otto Michael M Gao Qian Q
Infection and immunity 20050501 5
To test if biofilm formation in Staphylococcus epidermidis is dependent on the polysaccharide intercellular adhesin, whose biosynthesis is driven by the ica locus, a plasmid containing the ica locus was transferred to three ica-negative strains. Using in vitro biofilm assays and a rat central venous catheter infection model, we confirmed the importance of the ica locus for biofilm production and pathogenesis of S. epidermidis. ...[more]
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