Transgenic engineering of male-specific muscular hypertrophy.
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ABSTRACT:
SUBMITTER: Pirottin D
PROVIDER: S-EPMC1088392 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Publications
Transgenic engineering of male-specific muscular hypertrophy.
Pirottin Dimitri D Grobet Luc L Adamantidis Antoine A Farnir Frédéric F Herens Christian C Schrøder Henrik Daa HD Georges Michel M
Proceedings of the National Academy of Sciences of the United States of America 20050425 18
Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more ef ...[more]
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