Ontology highlight
ABSTRACT:
SUBMITTER: Stauffer BL
PROVIDER: S-EPMC4449792 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Stauffer Brian L BL Dockstader Karen K Russell Gloria G Hijmans Jamie J Walker Lisa L Cecil Mackenzie M Demos-Davies Kimberly K Medway Allen A McKinsey Timothy A TA Sucharov Carmen C CC
Biochemical and biophysical research communications 20150429 2
YY1 can activate or repress transcription of various genes. In cardiac myocytes in culture YY1 has been shown to regulate expression of several genes involved in myocyte pathology. YY1 can also acutely protect the heart against detrimental changes in gene expression. In this study we show that cardiac over-expression of YY1 induces pathologic cardiac hypertrophy in male mice, measured by changes in gene expression and lower ejection fraction/fractional shortening. In contrast, female animals are ...[more]