Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression.
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ABSTRACT:
SUBMITTER: Manly KF
PROVIDER: S-EPMC1088946 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression.
Manly Kenneth F KF Wang Jintao J Williams Robert W RW
Genome biology 20050228 3
Heritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). Transcribed RNA levels are often measured by hybridization to microarrays of oligonucleotide probes, in which each transcript is represented by multiple probes. The use of recombinant inbred lines allows an estimate of the heritability of expression measured by individual probes. This heritability varies greatly. We have tested heritability-weighted averages to define expression of a transcript and f ...[more]
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