Ontology highlight
ABSTRACT:
SUBMITTER: Daddacha W
PROVIDER: S-EPMC10894040 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Daddacha Waaqo W Monroe Dominique D Schlafstein Ashley J AJ Withers Allison E AE Thompson Elizabeth B EB Danelia Diana D Luong Nho C NC Sesay Fatmata F Rath Sandip K SK Usoro Edidiong R ER Essien Mark E ME Jung Andrew T AT Jiang Jinmeng G JG Hu Jiaxuan J Mahboubi Bijan B Williams Arilyn A Steinbeck Julia E JE Yang Xiaofeng X Buchwald Zachary S ZS Dynan William S WS Switchenko Jeffrey M JM Kim Baek B Khan Mohammad K MK Jaye David L DL Yu David S DS
NAR cancer 20240224 1
Diffuse large B-cell lymphoma (DLBCL) is a commonly diagnosed, aggressive non-Hodgkin's lymphoma. While R-CHOP chemoimmunotherapy is potentially curative, about 40% of DLBCL patients will fail, highlighting the need to identify biomarkers to optimize management. SAMHD1 has a dNTPase-independent role in promoting resection to facilitate DNA double-strand break (DSB) repair by homologous recombination. We evaluated the relationship of SAMHD1 levels with sensitivity to DSB-sensitizing agents in DLB ...[more]