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Biomarkers for dementia in Latin American countries: Gaps and opportunities.


ABSTRACT: Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

SUBMITTER: Parra MA 

PROVIDER: S-EPMC10906502 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Biomarkers for dementia in Latin American countries: Gaps and opportunities.

Parra Mario A MA   Orellana Paulina P   Leon Tomas T   Victoria Cabello G CG   Henriquez Fernando F   Gomez Rodrigo R   Avalos Constanza C   Damian Andres A   Slachevsky Andrea A   Ibañez Agustin A   Zetterberg Henrik H   Tijms Betty M BM   Yokoyama Jennifer S JS   Piña-Escudero Stefanie D SD   Cochran J Nicholas JN   Matallana Diana L DL   Acosta Daisy D   Allegri Ricardo R   Arias-Suárez Bianca P BP   Barra Bernardo B   Behrens Maria Isabel MI   Brucki Sonia M D SMD   Busatto Geraldo G   Caramelli Paulo P   Castro-Suarez Sheila S   Contreras Valeria V   Custodio Nilton N   Dansilio Sergio S   la Cruz-Puebla Myriam De M   de Souza Leonardo Cruz LC   Diaz Monica M MM   Duque Lissette L   Farías Gonzalo A GA   Ferreira Sergio T ST   Guimet Nahuel Magrath NM   Kmaid Ana A   Lira David D   Lopera Francisco F   Meza Beatriz Mar BM   Miotto Eliane C EC   Nitrini Ricardo R   Nuñez Alberto A   O'Neill Santiago S   Ochoa John J   Pintado-Caipa Maritza M   Resende Elisa de Paula França EPF   Risacher Shannon S   Rojas Luz Angela LA   Sabaj Valentina V   Schilling Lucas L   Sellek Allis F AF   Sosa Ana A   Takada Leonel T LT   Teixeira Antonio L AL   Unaucho-Pilalumbo Martha M   Duran-Aniotz Claudia C  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20220913 2


Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appea  ...[more]

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