NPHS2 Mutations: A Closer Look to Latin American Countries.
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ABSTRACT:
SUBMITTER: Guaragna MS
PROVIDER: S-EPMC5529630 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
<i>NPHS2</i> Mutations: A Closer Look to Latin American Countries.
Guaragna Mara Sanches MS Lutaif Anna Cristina G B ACGB Maciel-Guerra Andréa T AT Belangero Vera M S VMS Guerra-Júnior Gil G De Mello Maricilda P MP
BioMed research international 20170712
Nephrotic syndrome is one of the most common kidney pathologies in childhood, being characterized by proteinuria, edema, and hypoalbuminemia. In clinical practice, it is divided into two categories based on the response to steroid therapy: steroid-sensitive and steroid resistant. Inherited impairments of proteins located in the glomerular filtration barrier have been identified as important causes of nephrotic syndrome, with one of these being podocin, coded by <i>NPHS2</i> gene. <i>NPHS2</i> mu ...[more]
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