Ontology highlight
ABSTRACT:
SUBMITTER: Das P
PROVIDER: S-EPMC10908869 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Das Palamou P Chakrabarti Oishee O
Cell death & disease 20240302 3
Dynamin related protein 1 (DRP1), a pivotal mitochondrial fission protein, is post-translationally modified by multiple mechanisms. Here we identify a new post-translational modification of DRP1 by the ubiquitin-like protein, interferon-stimulated gene 15 (ISG15). DRP1 ISGylation is mediated by ISG15 E3 ligase, HERC5; this promotes mitochondrial fission. DeISGylation of DRP1 however leads to hyperfusion. Heterologous expression of SARS-CoV2 PLpro, a deISGylating enzyme, results in similar mitoch ...[more]