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Opportunities and challenges for anti-CD47 antibodies in hematological malignancies.

ABSTRACT: CD47 is a cell-surface ligand that is overexpressed in various malignancies and that binds to SIRPα on macrophages to promote tumor cell evasion of phagocytosis. Blocking the CD47-SIRPα axis can increase the phagocytosis of macrophages to exert antitumor effects. CD47-based immunotherapy is a current research focus. The combination of anti-CD47 antibodies with other drugs has shown encouraging response rates in patients with hematological tumors, but side effects also occur. Bispecific antibodies and SIRPα/Fc fusion proteins appear to balance the efficacy and safety of treatment. We review the latest clinical research advances and discuss the opportunities and challenges associated with CD47-based immunotherapy for hematological malignancies.

SUBMITTER: Xu Y

PROVIDER: S-EPMC10920290 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Opportunities and challenges for anti-CD47 antibodies in hematological malignancies.

Xu Yilan Y Jiang Panruo P Xu Zhenyan Z Ye Haige H

Frontiers in immunology 20240223

CD47 is a cell-surface ligand that is overexpressed in various malignancies and that binds to SIRPα on macrophages to promote tumor cell evasion of phagocytosis. Blocking the CD47-SIRPα axis can increase the phagocytosis of macrophages to exert antitumor effects. CD47-based immunotherapy is a current research focus. The combination of anti-CD47 antibodies with other drugs has shown encouraging response rates in patients with hematological tumors, but side effects also occur. Bispecific antibodie ...[more]

PMID: 38464520

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