Ontology highlight
ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC8455363 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Sun Jennifer J Chen Yixuan Y Lubben Berit B Adebayo Ola O Muz Barbara B Azab Abdel Kareem AK
Leukemia research reports 20210914
CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the "don't-eat-me" signal. However, accumulating evidence shows that solid and hematologic tumor cells overexpress CD47 to escape immune surveillance. Thus, targeting the CD47-SIRPa axis by limiting the activity of this checkpoint has emerged as a key area of research. In this review, we will provide an update on the landscape of CD47-ta ...[more]