Ontology highlight
ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC10928583 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Zhao Limin L Tang Pingping P Lin Yuan Y Du Menghan M Li Huimin H Jiang Lintong L Xu Henghui H Sun Heyang H Han Jingjing J Sun Zeqi Z Xu Run R Lou Han H Chen Zhouxiu Z Kopylov Philipp P Liu Xin X Zhang Yong Y
Aging cell 20231214 3
Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD<sup>+</sup> depletion is a hallmark feature of aging heart, however, the molecular mechanisms that affect NAD<sup>+</sup> depletion remain unclear. In this study, we identified microRNA-203 (miR-203) as a senescence-associated microRNA that regulates NAD<sup>+</sup> homeostasis. We found that the blood miR-203 level negatively correlated with human age and its expression significantly decreased in the hearts of ag ...[more]