Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Thrombotic ST-segment elevation myocardial infarction caused by a caseous mitral annular calcification.

ABSTRACT:

SUBMITTER: Al-Kassou B

PROVIDER: S-EPMC10954851 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Thrombotic ST-segment elevation myocardial infarction caused by a caseous mitral annular calcification.

Al-Kassou Baravan B Weber Marcel M Nickenig Georg G Zimmer Sebastian S

Clinical research in cardiology : official journal of the German Cardiac Society 20230221 4

PMID: 36809351

Similar Datasets

Recurrent ST-elevation myocardial infarction: a case report of a rare complication of caseous mitral annular calcification.

Project description:BackgroundCaseous mitral annular calcification (MAC) is an under-diagnosed division of calcific mitral valve disease that has recently been reported to have increased propensity for embolic disease. Early recognition of this entity as a cause of embolic disease can lead to prevention of occlusive vascular disease and long-standing complications.Case summaryWe present the case of a patient with end-stage renal disease who presented for evaluation of chest pain and was found to have ST-segment myocardial infarction. Despite thrombectomy and stenting, he had multiple recurrent events, and imaging evaluation demonstrated caseous MAC with mobile components. He was taken for surgical replacement of the mitral valve, with pathology confirming diagnosis.DiscussionCaseous MAC may represent an increased risk of embolic disease. Better understanding of this pathology and it's propensity for embolic disease will be important to best determine treatment plans and timing of operative intervention.

| S-EPMC8759494 | biostudies-literature

Myocardial infarction induced by caseous mitral annular calcification: a case report.

Project description:BackgroundCaseous mitral annular calcification (CMAC) is a rare variant of mitral annular calcification. Symptoms can be related to mitral valvular dysfunction, arterial embolization, and transient aortic outflow tract obstruction. CMAC usually affects the posterior fibrous mitral annulus and is commonly diagnosed in elderly patients with a history of hypertension, dyslipidaemia, and renal failure.Case summaryA 68-year-old patient was transferred to our department for late presenting acute myocardial infarction and acute heart failure. Coronary angiography revealed a significant extrinsic compression of the circumflex artery. Transthoracic echocardiography revealed an ovoid calcified mass of 3.6 cm × 2 cm originating from the posterior mitral annulus causing moderate mitral stenosis as well as akinesia of the inferolateral wall, reduced left ventricle ejection fraction (35%), and a low-flow low-gradient severe aortic stenosis. Cardiac computed tomography scan confirmed the presence of a large calcified mass, inserted to the posterior mitral annulus evocating caseous necrosis. The patient underwent a double valve replacement with implantation of both aortic and mitral bioprostheses. Histopathology of the excised mass revealed a chronic mitral valve fibrocalcification with aseptic necrosis, consistent with a caseous calcification of the posterior mitral annulus.DiscussionExtrinsic coronary artery compression is a rare disease entity. We report a rather peculiar cause of extrinsic artery compression: CMAC inducing significant mitral stenosis and compressing the circumflex artery leading to myocardial infarction. To the best of our knowledge, this is the first case of extrinsic artery compression caused by CMAC.

| S-EPMC10398422 | biostudies-literature

Large caseous mitral annular calcification with mitral stenosis, dynamic left ventricular outflow obstruction, and syncope.

Project description: Not available

| S-EPMC3528210 | biostudies-literature

ST-segment elevation myocardial infarction after COVID-19 reinfection: The disseminated thrombotic process.

Project description: Not available

| S-EPMC8747836 | biostudies-literature

Multiple Cardioembolic Strokes Caused by Caseous Calcification of the Mitral Annulus.

Project description:Highlights•Mitral annular calcification (MAC) is a common echocardiographic finding, estimated at around 14%, and occurs especially in elderly women.•Caseous calcification of the mitral annulus (CCMA) is a rare subvariant of MAC, with an echocardiographic prevalence of 0.6% and necropsy prevalence of about 2.3%.•CCMA, just like MAC, is believed to be associated with a high calcium score, coronary artery disease, aortic valve disease, atrial fibrillation, and hypertension.•CCMA can be confused echocardiographically with infective endocarditis, tumors, and cysts.•The decision for surgical treatment of CCMA is based on clinical judgment with factors such as valvular dysfunction and/or the propensity for stroke.

| S-EPMC6034490 | biostudies-other

Caseous calcification of the mitral annulus.

Project description: Not available

| S-EPMC2435443 | biostudies-literature

The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction.

Project description:It is assumed that platelets in diseased conditions share similar properties to platelets in healthy conditions, although this has never been examined in detail for myocardial infarction (MI). We examined platelets from patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) compared with platelets from healthy volunteers to evaluate for differences in platelet phenotype and function. Platelet activation was examined and postreceptor signal transduction pathways were assessed. Platelet-derived plasma biomarkers were evaluated by receiver operator characteristic curve analysis. Maximum platelet activation through the thromboxane receptor was greater in STEMI than in NSTEMI but less through protease-activated receptor 1. Extracellular-signal related-kinase 5 activation, which can activate platelets, was increased in platelets from subjects with STEMI and especially in platelets from patients with NSTEMI. Matrix metalloproteinase 9 (MMP9) protein content and enzymatic activity were several-fold greater in platelets with MI than in control. Mean plasma MMP9 concentration in patients with MI distinguished between STEMI and NSTEMI (area under curve [AUC] 75% [confidence interval (CI) 60-91], P = 0.006) which was superior to troponin T (AUC 66% [CI 48-85, P = 0.08), predicting STEMI with 80% sensitivity (95% CI 56-94), 90% specificity (CI 68-99), 70% AUC (CI 54-86, P < 0.0001), and NSTEMI with 50% sensitivity (CI 27-70), 90% specificity (CI 68-99), 70% AUC (CI 54-86, P = 0.03). Platelets from patients with STEMI and NSTEMI show differences in platelet surface receptor activation and postreceptor signal transduction, suggesting the healthy platelet phenotype in which antiplatelet agents are often evaluated in preclinical studies is different from platelets in patients with MI.

| S-EPMC5898983 | biostudies-literature

ST-Segment Elevation Myocardial Infarction Caused by Embolized Transcatheter Aortic Valve in Ascending Aorta.

Project description:ObjectiveEmbolized valves during transcatheter aortic valve replacement can cause myocardial ischemia by obstructing diastolic retrograde blood flow.Key stepsTo prove the described mechanism of ischemia, we performed aortography with catheter above the embolized valve and placed a stiff wire through the embolized valve, causing leaflet opening while monitoring electrocardiogram. As a treatment method, an aortic stent was implanted from the embolized valve into the aortic arch, enabling backflow and resolving the ischemia.Potential pitfallsOverlooking the described cause of ischemia is the biggest pitfall because it can be diagnosed and treated using simple techniques.Take-home messagesEmbolized transcatheter aortic valve replacement valve can cause myocardial ischemia by blocking the diastolic backflow of blood. Aortography and opening of the embolized valve leaflets with wire can be used for diagnosis, and aortic stent implantation in the embolized valve can be used as a treatment modality.

| S-EPMC11830255 | biostudies-literature

Percutaneous Retrieval of an Embolized Transcatheter Mitral Valve Repair Clip Causing ST-Segment Elevation Myocardial Infarction.

Project description:Mitral valve repair clip detachment and embolization is a rare phenomenon, with few reported cases. We describe a case of subacute transcatheter mitral valve repair clip embolization presenting as an inferior ST-segment elevation myocardial infarction, with subsequent successful percutaneous device retrieval. (Level of Difficulty: Intermediate.).

| S-EPMC9998723 | biostudies-literature

Symptomatic Left Ventricular Outflow Tract Obstruction Caused by Mitral Annular Calcification.

Project description: Not available

| S-EPMC7756159 | biostudies-literature