Dataset Information
Temporal course of cognitive and behavioural changes in motor neuron diseases.
Ontology highlight
ABSTRACT: Background
Cognitive and behavioural dysfunction may occur in people with motor neuron disease (MND), with some studies suggesting an association with the C9ORF72 repeat expansion. Their onset and progression, however, is poorly understood. We explored how cognition and behaviour change over time, and whether demographic, clinical and genetic factors impact these changes.Methods
Participants with MND were recruited through the Phenotype-Genotype-Biomarker study. Every 3-6 months, the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was used to assess amyotrophic lateral sclerosis (ALS) specific (executive functioning, verbal fluency, language) and ALS non-specific (memory, visuospatial) functions. Informants reported on behaviour symptoms via semi-structured interview.Results
Participants with neuropsychological data at ≥3 visits were included (n=237, mean age=59, 60% male), of which 18 (8%) were C9ORF72 positive. Baseline cognitive impairment was apparent in 18 (8%), typically in ALS specific domains, and associated with lower education, but not C9ORF72 status. Cognition, on average, remained stable over time, with two exceptions: (1) C9ORF72 carriers declined in all ECAS domains, (2) 8%-9% of participants with baseline cognitive impairment further declined, primarily in the ALS non-specific domain, which was associated with less education. Behavioural symptoms were uncommon.Conclusions
In this study, cognitive dysfunction was less common than previously reported and remained stable over time for most. However, cognition declines longitudinally in a small subset, which is not entirely related to C9ORF72 status. Our findings raise questions about the timing of cognitive impairment in MND, and whether it arises during early clinically manifest disease or even prior to motor manifestations.
SUBMITTER: McHutchison CA
PROVIDER: S-EPMC10958376 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
Temporal course of cognitive and behavioural changes in motor neuron diseases.
Journal of neurology, neurosurgery, and psychiatry 20240313 4
<h4>Background</h4>Cognitive and behavioural dysfunction may occur in people with motor neuron disease (MND), with some studies suggesting an association with the <i>C9ORF72</i> repeat expansion. Their onset and progression, however, is poorly understood. We explored how cognition and behaviour change over time, and whether demographic, clinical and genetic factors impact these changes.<h4>Methods</h4>Participants with MND were recruited through the Phenotype-Genotype-Biomarker study. Every 3-6 ...[more]
