Ontology highlight
ABSTRACT:
SUBMITTER: Hilwi M
PROVIDER: S-EPMC10959965 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Hilwi Maram M Shulman Katherina K Naroditsky Inna I Feld Sari S Gross-Cohen Miriam M Boyango Ilanit I Soboh Soaad S Vornicova Olga O Farhoud Malik M Singh Preeti P Bar-Sela Gil G Goldberg Hadassah H Götte Martin M Sharrocks Andrew D AD Li Yaoyong Y Sanderson Ralph D RD Ilan Neta N Vlodavsky Israel I
Cell death & disease 20240322 3
Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we found that patients endowed with high levels of Hpa2 exhibited a higher incidence of tumor metastasis and survived less than patients with low levels of Hpa2. Immunohistochemical examination revealed that in normal breast tissue, Hpa2 localizes primarily in th ...[more]