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Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054.


ABSTRACT: The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10970339 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054.

Wang Qinghua Q   Zhao Jing J   Liu Zhaoyuan Z   Ding Shaoxiong S   Huang Zhiyong Z   Chen Jun J  

International journal of molecular sciences 20240308 6


The marine bacterium <i>Streptomyces</i> sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respec  ...[more]

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