Dataset Information

Effects of occupational exposure to metal fume PM_2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

ABSTRACT:

Objective

This study investigates the associations of α1-antitrypsin, inter-α-trypsin inhibitor heavy chain (ITIH4), and 8-isoprostane with lung function in shipyard workers exposed to occupational metal fume fine particulate matter (PM_2.5), which is known to be associated with adverse respiratory outcomes.

Methods

A 3-year follow-up study was conducted on 180 shipyard workers with 262 measurements. Personal exposure to welding fume PM_2.5 was collected for an 8-h working day. Pre-exposure, post-exposure, and delta (∆) levels of α1-antitrypsin, ITIH4, and 8-isoprostane were determined in urine using enzyme-linked immunosorbent assays. Post-exposure urinary metals were sampled at the beginning of the next working day and analyzed by inductively coupled plasma-mass spectrometry. Lung function measurements were also conducted the next working day for post-exposure.

Results

An IQR increase in PM_2.5 was associated with decreases of 2.157% in FEV₁, 2.806% in PEF, 4.328% in FEF_25%, 5.047% in FEF_50%, and 7.205% in FEF_75%. An IQR increase in PM_2.5 led to increases of 42.155 µg/g in ∆α1-antitrypsin and 16.273 µg/g in ∆ITIH4. Notably, IQR increases in various urinary metals were associated with increases in specific biomarkers, such as post-urinary α1-antitrypsin and ITIH4. Moreover, increases in ∆ α1-antitrypsin and ∆ITIH4 were associated with decreases in FEV₁/FVC by 0.008% and 0.020%, respectively, and an increase in ∆8-isoprostane resulted in a 1.538% decline in FVC.

Conclusion

Our study suggests that urinary α1-antitrypsin and ITIH4 could indicate early lung function decline in shipyard workers exposed to metal fume PM_2.5, underscoring the need for better safety and health monitoring to reduce respiratory risks.

SUBMITTER: Tran HM

PROVIDER: S-EPMC10999385 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of occupational exposure to metal fume PM<sub>2.5</sub> on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Tran Huan Minh HM Lai Ching-Huang CH Chen Wei-Liang WL Wang Chung Ching CC Liang Che-Wei CW Chien Chi-Yu CY Pan Chih-Hong CH Chuang Kai-Jen KJ Chuang Hsiao-Chi HC

International archives of occupational and environmental health 20240313 4

<h4>Objective</h4>This study investigates the associations of α1-antitrypsin, inter-α-trypsin inhibitor heavy chain (ITIH4), and 8-isoprostane with lung function in shipyard workers exposed to occupational metal fume fine particulate matter (PM<sub>2.5</sub>), which is known to be associated with adverse respiratory outcomes.<h4>Methods</h4>A 3-year follow-up study was conducted on 180 shipyard workers with 262 measurements. Personal exposure to welding fume PM<sub>2.5</sub> was collected for an ...[more]

PMID: 38480609

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Dataset Information

Effects of occupational exposure to metal fume PM_2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Objective

Methods

Results

Conclusion

Publications

Effects of occupational exposure to metal fume PM<sub>2.5</sub> on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Effects of occupational exposure to metal fume PM2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Objective

Methods

Results

Conclusion

Publications

Effects of occupational exposure to metal fume PM<sub>2.5</sub> on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Effects of occupational exposure to metal fume PM_2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.