Ontology highlight
ABSTRACT:
SUBMITTER: Fumagalli V
PROVIDER: S-EPMC11003867 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Fumagalli Valeria V Ravà Micol M Marotta Davide D Di Lucia Pietro P Bono Elisa B EB Giustini Leonardo L De Leo Federica F Casalgrandi Maura M Monteleone Emanuele E Mouro Violette V Malpighi Chiara C Perucchini Chiara C Grillo Marta M De Palma Sara S Donnici Lorena L Marchese Silvia S Conti Matteo M Muramatsu Hiromi H Perlman Stanley S Pardi Norbert N Kuka Mirela M De Francesco Raffaele R Bianchi Marco E ME Guidotti Luca G LG Iannacone Matteo M
Nature immunology 20240314 4
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under the presumption that it is the primary defense mechanism following vaccination or infection. This perspective, however, can overlook the role of T cells, particularly when antibody levels are low or absent. Here we show, through studies in mouse m ...[more]