Ontology highlight
ABSTRACT:
SUBMITTER: Keyport Kik S
PROVIDER: S-EPMC11009240 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Keyport Kik Samantha S Christopher Dana D Glauninger Hendrik H Hickernell Caitlin Wong CW Bard Jared A M JAM Lin Kyle M KM Squires Allison H AH Ford Michael M Sosnick Tobin R TR Drummond D Allan DA
Nature communications 20240411 1
Cells must sense and respond to sudden maladaptive environmental changes-stresses-to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures known as stress granules under severe stress. The composition, formation mechanism, adaptive significance, and even evolutionary conservation of these condensed structures remain enigmatic. Here we pro ...[more]