Ontology highlight
ABSTRACT:
SUBMITTER: Ukmar-Godec T
PROVIDER: S-EPMC6606616 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ukmar-Godec Tina T Hutten Saskia S Grieshop Matthew P MP Rezaei-Ghaleh Nasrollah N Cima-Omori Maria-Sol MS Biernat Jacek J Mandelkow Eckhard E Söding Johannes J Dormann Dorothee D Zweckstetter Markus M
Nature communications 20190702 1
Cells form and use biomolecular condensates to execute biochemical reactions. The molecular properties of non-membrane-bound condensates are directly connected to the amino acid content of disordered protein regions. Lysine plays an important role in cellular function, but little is known about its role in biomolecular condensation. Here we show that protein disorder is abundant in protein/RNA granules and lysine is enriched in disordered regions of proteins in P-bodies compared to the entire hu ...[more]