Ontology highlight
ABSTRACT:
SUBMITTER: Sorum B
PROVIDER: S-EPMC11009253 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Sorum Ben B Docter Trevor T Panico Vincent V Rietmeijer Robert A RA Brohawn Stephen G SG
Nature communications 20240411 1
TRAAK, TREK-1, and TREK-2 are mechanosensitive two-pore domain K+ (K2P) channels that contribute to action potential propagation, sensory transduction, and muscle contraction. While structural and functional studies have led to models that explain their mechanosensitivity, we lack a quantitative understanding of channel activation by membrane tension. Here, we define the tension response of mechanosensitive K2Ps using patch-clamp recording and imaging. All are low-threshold mechanosensitive chan ...[more]