Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt P
PROVIDER: S-EPMC11010340 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Schmitt Pauline P Duval Anais A Camus Mylène M Lefrançais Emma E Roga Stéphane S Dedieu Cécile C Ortega Nathalie N Bellard Elisabeth E Mirey Emilie E Mouton-Barbosa Emmanuelle E Burlet-Schiltz Odile O Gonzalez-de-Peredo Anne A Cayrol Corinne C Girard Jean-Philippe JP
The Journal of experimental medicine 20240410 6
Epithelium-derived cytokines or alarmins, such as interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), are major players in type 2 immunity and asthma. Here, we demonstrate that TNF-like ligand 1A (TL1A) is an epithelial alarmin, constitutively expressed in alveolar epithelium at steady state in both mice and humans, which cooperates with IL-33 for early induction of IL-9high ILC2s during the initiation of allergic airway inflammation. Upon synergistic activation by IL-33 and TL1A, lu ...[more]