Ontology highlight
ABSTRACT:
SUBMITTER: Nechama M
PROVIDER: S-EPMC5913134 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nechama Morris M Kwon Jeahoo J Wei Shuo S Kyi Adrian Tun AT Welner Robert S RS Ben-Dov Iddo Z IZ Arredouani Mohamed S MS Asara John M JM Chen Chun-Hau CH Tsai Cheng-Yu CY Nelson Kyle F KF Kobayashi Koichi S KS Israel Elliot E Zhou Xiao Zhen XZ Nicholson Linda K LK Lu Kun Ping KP
Nature communications 20180423 1
Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines mRNAs, but the function of PIN1 in upstream signaling pathways in asthma is unknown. Here we show that interleukin receptor associated kinase M (IRAK-M) is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simu ...[more]