Ontology highlight
ABSTRACT:
SUBMITTER: Bu S
PROVIDER: S-EPMC11011381 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Bu Shuhan S Singh Aman A Nguyen Hien C HC Peddi Bharatsinai B Bhatt Kriti K Ravendranathan Naresh N Frisbee Jefferson C JC Singh Krishna K KK
International journal of molecular sciences 20240331 7
Endothelial autophagy plays an important role in the regulation of endothelial function. The inhibition of endothelial autophagy is associated with the reduced expression of <i>protein disulfide isomerase 4</i> (<i>PDIA-4</i>); however, its role in endothelial cells is not known. Here, we report that endothelial cell-specific loss of PDIA-4 leads to impaired autophagic flux accompanied by loss of endothelial function and apoptosis. Endothelial cell-specific loss of PDIA-4 also induced marked cha ...[more]