Ontology highlight
ABSTRACT:
SUBMITTER: Kim YM
PROVIDER: S-EPMC6324937 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kim Young-Mee YM Youn Seock-Won SW Sudhahar Varadarajan V Das Archita A Chandhri Reyhaan R Cuervo Grajal Henar H Kweon Junghun J Leanhart Silvia S He Lianying L Toth Peter T PT Kitajewski Jan J Rehman Jalees J Yoon Yisang Y Cho Jaehyung J Fukai Tohru T Ushio-Fukai Masuko M
Cell reports 20180601 12
Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments reveal that PDIA1 d ...[more]