Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa-Saito Y
PROVIDER: S-EPMC11011437 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Nakagawa-Saito Yurika Y Mitobe Yuta Y Togashi Keita K Suzuki Shuhei S Sugai Asuka A Takenouchi Senri S Nakamura Kazuki K Sonoda Yukihiko Y Kitanaka Chifumi C Okada Masashi M
International journal of molecular sciences 20240402 7
The prevention of tumor recurrence by the successful targeting of glioma stem cells endowed with a tumor-initiating capacity is deemed the key to the long-term survival of glioblastoma patients. Glioma stem cells are characterized by their marked therapeutic resistance; however, recent evidence suggests that they have unique vulnerabilities that may be therapeutically targeted. We investigated MDM2 expression levels in glioma stem cells and their non-stem cell counterparts and the effects of the ...[more]