Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4058386 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Li Qin Q Zhang Yun Y El-Naggar Adel K AK Xiong Shunbin S Yang Peirong P Jackson James G JG Chau Gilda G Lozano Guillermina G
Molecular cancer research : MCR 20140305 6
<h4>Unlabelled</h4>The p53 (TP53) tumor suppressor is the most frequently mutated gene in human cancers. Restoring expression of wild-type p53 has led to tumor growth suppression in a variety of tumor models that are p53 deficient. Other mechanisms, for example, upregulation of Mdm2, exist in tumors to inactivate the p53 pathway. Mdm2, an E3 ubiquitin ligase that targets p53 for proteasomal degradation, is present at high levels in many tumors with wild-type p53. In this study, the effects of re ...[more]