Ontology highlight
ABSTRACT:
SUBMITTER: Ishii D
PROVIDER: S-EPMC11011476 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Ishii Daisuke D Kawasaki Takeshi T Sato Hironori H Tatsumi Koichiro K Imamoto Takuro T Yoshioka Keiichiro K Abe Mitsuhiro M Hasegawa Yoshinori Y Ohara Osamu O Suzuki Takuji T
International journal of molecular sciences 20240328 7
Two anti-fibrotic drugs, pirfenidone (PFD) and nintedanib (NTD), are currently used to treat idiopathic pulmonary fibrosis (IPF). Peripheral blood mononuclear cells (PBMCs) are immunocompetent cells that could orchestrate cell-cell interactions associated with IPF pathogenesis. We employed RNA sequencing to examine the transcriptome signature in the bulk PBMCs of patients with IPF and the effects of anti-fibrotic drugs on these signatures. Differentially expressed genes (DEGs) between "patients ...[more]