Ontology highlight
ABSTRACT:
SUBMITTER: Herazo-Maya JD
PROVIDER: S-EPMC4175518 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Herazo-Maya Jose D JD Noth Imre I Duncan Steven R SR Kim Sunghwan S Ma Shwu-Fan SF Tseng George C GC Feingold Eleanor E Juan-Guardela Brenda M BM Richards Thomas J TJ Lussier Yves Y Huang Yong Y Vij Rekha R Lindell Kathleen O KO Xue Jianmin J Gibson Kevin F KF Shapiro Steven D SD Garcia Joe G N JG Kaminski Naftali N
Science translational medicine 20131001 205
We aimed to identify peripheral blood mononuclear cell (PBMC) gene expression profiles predictive of poor outcomes in idiopathic pulmonary fibrosis (IPF) by performing microarray experiments of PBMCs in discovery and replication cohorts of IPF patients. Microarray analyses identified 52 genes associated with transplant-free survival (TFS) in the discovery cohort. Clustering the microarray samples of the replication cohort using the 52-gene outcome-predictive signature distinguished two patient g ...[more]