Ontology highlight
ABSTRACT:
SUBMITTER: Middonti E
PROVIDER: S-EPMC11014856 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Middonti Emanuele E Astanina Elena E Vallariello Edoardo E Hoza Roxana Maria RM Metovic Jasna J Spadi Rosella R Cristiano Carmen C Papotti Mauro M Allavena Paola P Novelli Francesco F Parab Sushant S Cappello Paola P Scarpa Aldo A Lawlor Rita R Di Maio Massimo M Arese Marco M Bussolino Federico F
EMBO reports 20240227 4
Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a dismal prognosis that arises from precursor lesions called pancreatic intraepithelial neoplasias (PanINs). Progression from low- to high-grade PanINs is considered as tumor initiation, and a deeper understanding of this switch is needed. Here, we show that synaptic molecule neuroligin-2 (NLGN2) is expressed by pancreatic exocrine cells and plays a crucial role in the regulation of contact inhibition and epithelial polarity, which characte ...[more]